To explore the potential anti‐obesity effects of CNNM4, We injected a recombinant adenovirus‐associated virus (AAV) expressing CNNM4 in scWAT of HFD‐fed mice, which led to overexpression of CNNM4 in scWAT but not in liver, muscle, BAT, or brain (Figure S21A, Supporting Information). This evidence concerns the gene CNNM4 and obesity due to melanocortin 4 receptor deficiency.