Depletion of HMGCR and FDPS genes and drugs (lovastatin, alendronate/zoledronate, and squalestatin 1) targeting specific HMGCR, FDPS, and FDFT1 enzymes impairs spheroid formation in colon cancer and glioblastoma [19, 21], implying an important role for cholesterol biosynthetic enzyme genes in stemness and tumorigenesis. The gene discussed is HMGCR; the disease is colonic neoplasm.