In the univariate Cox regression analysis, age, male sex, hypertension, serum albumin levels, eGFR, urine PCR, immunosuppressant use, mesangial hypercellularity, tubular atrophy/interstitial fibrosis, cellular or fibrocellular crescents, and urinary mRNA levels of FLOT1, Nephrin, and TfR showed a significant association with CKD progression in patients with IgAN. The gene discussed is NPHS1; the disease is chronic kidney disease.