TP53 and leukoencephalopathy with calcifications and cysts: In our previous study in patients with metastatic CRC, mutp53 overall was not associated with prognosis, similar to our current finding in advanced STS; however, hotspot mutp53 was associated with worse OS than non-hotspot mutp53 in left-sided CRC (LCC) but not in right-sided CRC (RCC), while RCC was associated with worse OS than LCC only in patients with non-hotspot TP53.