Other remarkable HRs of DCS vs CS in terms of OS were 0.259 in DPYD rs2297595 TC (vs 0.514 in TT), 1.777 in ABCB1 rs7787082 AA (vs 0.435 in GA and 0.426 in GG), 0.237 in XRCC2 rs1799782 AA (vs 0.499 GA and 0.678 in GG) (Supplementary Table 2). Here, XRCC2 is linked to Cowden syndrome 1.