RPE65 and Leber congenital amaurosis: The high level of precision achieved with prime editing has also recently been employed in 2 mouse models of LCA, with dual AAV delivery to the subretinal space [66, 67] correcting pathogenic mutations with up to 16% efficiency, with no detectable off-target edits, restoring RPE65 expression, rescuing retinal and visual function, and preserving photoceptors.