Analysis of previously published22,23 single-cell sequencing data from human CD8+ intratumoral T cells showed that human Tex cells also expressed SLC16A11, with a particularly high expression in HNSCC-infiltrating CD8+ T cells coexpressing HAVCR2 and PDCD1, with minimal representation of these clusters in peripheral blood mononuclear cells (PBMCs) (Fig. 1g). Here, PDCD1 is linked to head and neck squamous cell carcinoma.