The blockade of MCT11 in MEER-bearing mice resulted in increased total CD8+ T cells infiltrating the tumor (Extended Data Fig. 9c,d), no numerical change in the CD8+ TIL subpopulations (Fig. 5d) and increased CD8+ polyfunctionality specifically in the exhausted subpopulation (Fig. 5e). The gene discussed is CD8A; the disease is neoplasm.