A sub-analysis of BRCA2/ATM carriers in our cohort suggested a younger age at CRPC diagnosis (P = 0.08) and a shorter interval between initial PC diagnosis and CRPC onset (P = 0.04) compared with non-carriers, in keeping with our previous findings of BRCA association with aggressive PrCa [1]. The gene discussed is BRCA2; the disease is pachyonychia congenita.