Periodontitis is a chronic disease that may be linked to several systemic diseases and is associated with the production of biomarkers like B-type natriuretic propeptide (NT-proBNP), α1-antitrypsin, C-reactive protein (hs-CRP), and endothelial cell-specific molecule-1 (ECM-1)5. The gene discussed is CRP; the disease is periodontitis.