The model was adjusted for factors known to be associated with differences in stress MBF and MPR including age, sex, LVEF, LV mass, LVEDV, hypertension, evidence of previous PCI, CABG surgery, MI, body surface area (BSA) and ethnicity as well as for medications including CCBs, nitrates, SGLT-2 inhibitors, GLP-1 agonists and gliclazide. This evidence concerns the gene GCG and hypertensive disorder.