The variables included in estimating the propensity score consisted of: age, sex, LVEF, LVEDV, hypertension, evidence of previous PCI, CABG or MI, BSA and ethnicity as well as medications including CCBs, nitrates, SGLT-2 inhibitors, GLP-1 agonists and gliclazide. The gene discussed is GCG; the disease is Hypertension.