Intriguingly, while CXCL2 was expressed by fibroblasts from all skin cancer types, melanoma-derived CAFs expressed high levels of CXCL1-3, 5, 6 and 8 and IL1B as well as IL6, whereas the expression of CXCL9-11 and 13 was high in non-melanoma CAFs (Fig. 6A). Here, CXCL2 is linked to skin neoplasm.