We investigated the expression of matrix-associated genes (collagens, laminins, lysyloxidases, and other ECM genes) and immune response or cancer invasion-associated genes (MMPs, chemokines, interleukins, and immunomodulatory genes) by module scores and found a significant enrichment of matrix-associated genes in mCAFs and immuno/invasiveness-associated genes in iCAFs (Fig. S8A and S8B). This evidence concerns the gene LAMB2 and cancer.