Decreased Crh mRNA levels in the PVN and corticosterone levels in the serum were observed in MPS-treated ONFH mice relative to vehicle-treated healthy mice and in mice treated with MPS daily for 1 and 3 days relative to mice treated with vehicle (Fig. S3a, b), suggesting that repression of the HPA axis occurred in both the early-stages and late-stages of MPS-treated ONFH mice. Here, CRH is linked to mucopolysaccharidosis.