ADRB2 and mucopolysaccharidosis: HE staining revealed that Adrb2 knockout induced a more severe ONFH phenotype in MPS-treated mice, as evidenced by the higher empty osteocytic lacunae in the trabecular bones and much larger areas of aberrant bone marrow structures filled with more anomalous cells, granular eosinophilic material, and fat vacuoles in the Adrb2−/− mice relative to their wild-type littermates (Fig. 5g); and this phenotype was unable to ameliorate following RU486 treatment in the PVN in the femoral heads of MPS-treated Adrb2−/− mice (Fig. 5g).