Intriguingly, a specific vessel, named the H-type (CD31hiEMCNhi) vessel, which spatiotemporally orchestrates the coupling of angiogenesis and osteogenesis, was markedly reduced in MPS-treated mice with ONFH relative to vehicle-treated control mice, as shown by co-immunostaining for CD31 and EMCN (Fig. 2u, w). This evidence concerns the gene PECAM1 and mucopolysaccharidosis.