To measure Adrb2 levels clinically, we found that Adrb2 expression was not significantly different in the femoral heads of late-stage GC-induced ONFH patient tissue relative to normal femoral head tissue, consistent with the comparison of the mice with MPS-induced ONFH to the vehicle-treated mice, as shown by Western blotting and qRT-PCR analysis (Fig. 4h, i). The gene discussed is ADRB2; the disease is mucopolysaccharidosis.