ADRB2 and mucopolysaccharidosis: Adrb2 is a component within the NE receptor, which change the sensitivity of cells to NE.69 Among bone-related cells, only ECs in the early stage in MPS-treated mice had higher Adrb2 mRNA levels than the controls, indicating that elevated expression of Adrb2 in ECs in the femoral head is compensated to the decreased sympathetic tone and increase sympathetic sensitivity.