Adrb2 signaling has a wide range of functions, helps with facilitating metabolism homeostasis and promoting angiogenesis.35 Chronic stress promotes tumor growth and angiogenesis by activating Adrb2 signaling.33,34 Here, Adrb2 agonist treatment alleviated GC-induced osteonecrosis and promoted H-type vessel angiogenesis coupled with osteogenesis. The gene discussed is ADRB2; the disease is osteonecrosis.