Although sympathetic denervation in MPS-treated mice exhibited a more severe ONFH phenotype, including much larger areas of aberrant bone marrow and microarchitecture filled with more anomalous cells, granular eosinophilic material, and fat vacuoles relative to the mice with MPS treatment only, Adrb2 activation was sufficient to protect the femoral heads from more devastating changes in these mice (Fig. 4m). This evidence concerns the gene ADRB2 and mucopolysaccharidosis.