TRIB3 and metabolic dysfunction-associated steatohepatitis: Transcriptomics of liver tissues identified 218 putatively significantly downregulated genes in Mist1KO mice compared to WT mice at 8 weeks after CCl4 treatment; among these, 17 genes showed a positive correlation with MIST1 in the CCl4-treated WT group (Figs. 5B, D and S6A–C), as was the case in the array data from MASH patients (Fig. S6D), with the highest predictive accuracy found for Trib3 (Fig. 5B–D).