SNCA and synucleinopathy: Others have suggested that the higher baseline pS129 α-synuclein point to the olfactory bulb as a regional nucleation point for the spread of synucleinopathy throughout the brain20, however, our data indicate that this would have to occur in the absence of significant increases in total, proportional pS129 α-synuclein or aggregated α-synuclein in this region (Figs. 4c, e and 6e, f).