For example, SNORA42 knockdown inhibits proliferation and self-renewal of non-small cell lung cancer cells, and SNORD126 promotes the growth of hepatocellular and colon cancer cells by activating the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/AKT) signaling pathway [13]. Here, AKT1 is linked to malignant colon neoplasm.