These results suggested that SNORD51 competitively binds to WDR33 with 3’ UTR of ZBED6 mRNA and inhibits the polyadenylation of 3’ UTR of ZBED6 mRNA by WDR33, thus downregulating the expression of ZBED6 mRNA in GBM cells. The gene discussed is ZBED6; the disease is glioblastoma.