By ranking LogFC, top 10 upregulated protein coding genes were selected to make a Venn diagram in GBM cells after the knockdown of SNORD51 and results showed that ZBED6 and TMEM132C were upregulated in GBM cells with the knockdown of SNORD51 (Supplementary Fig. 4B). This evidence concerns the gene TMEM132C and glioblastoma.