Based on the above experimental results, this study demonstrated that the upregulation of KHDRBS1 in GBM cells inhibited the ability of SNORD51 to competitively bind to WDR33 with ZBED6 pre-mRNA through binding to SNORD51 and thus promoted the 3’ end processing of ZBED6 pre-mRNA. Here, KHDRBS1 is linked to glioblastoma.