Natural elimination of cancer cells is mediated by human leucocyte antigen (HLA) Class I and II molecules [1] that bind to tumour protein fragments, move to the tumour cell surface and engage CD8+ lymphocytes for killing the tumour cell (HLA Class I) and CD4+ lymphocytes for antibody production against the tumour cell (HLA Class II). The gene discussed is CD8A; the disease is neoplasm.