As anticipated, in both sets of nude mice (those harboring pCDH-NC and those harboring pCDH-shSRI pancreatic cancer cells), intratumoral administration of CCL5 and serpin E1 led to elevated fasting blood glucose levels (Fig. 5j) and reduced fasting insulin levels (Fig. 5k) compared with those in the PBS group. This evidence concerns the gene CCL5 and familial pancreatic carcinoma.