The identified modules and pathways could contribute to peritoneal mesothelioma development and progression (see Discussion), including dysregulated chromosome segregation, covalent chromatin modification, altered mRNA metabolic processes, disrupted translation, post-translational events, activation of transmembrane receptor protein tyrosine kinase pathways, disrupted cell–cell junction assembly, and cytokine signalling, particularly interleukin-6 production. Here, IL6 is linked to peritoneal mesothelioma.