This network highlighted the potential shared immune pathways that could contribute to tumour invasion and metastasis in both subtypes [49], notably IL-17 signalling via its modulator IKBKE [50] and TH17 cell differentiation via five genes, namely, MPeM-associated HSP90AA1 and HSP90AB1, MPM-associated JUN and MAPK8, and MPM-associated membrane protein MUC1 widely implicated in mesothelioma malignancy [51]. This evidence concerns the gene MAPK8 and mesothelioma.