YY1 and Familial prostate cancer: A recent study applied H3K27ac-ChIP-seq in M2 macrophages and THP-1 cells and revealed that M2-specific enhancers were enriched in Yin Yang, 2 zinc finger nuclear transcription factor (YY1) signals, while YY1 increased macrophage-induced prostate cancer progression by upregulating IL-6 [240].