MRC1 and breast carcinoma: Hughes R. and others demonstrated that MRC1+TIE2HiCXCR4Hi TAMs accumulate around blood vessels in both LLC1 tumors and orthotopic 4T1 and MMTV-PyMT implants after chemotherapeutic impact, as well as in human breast carcinomas after neoadjuvant treatment with paclitaxel [199].