When adjusted by TF ( < 10% vs. ≥ 10%), metastatic burden; high burden defined by ≥ 4 bone metastasis or visceral metastasis (high vs low), and Gleason grade group (group ≤ 4 vs. 5), HRR defect was associated with shorter time to CRPC in ADT/CAB (HR, 6.12: 95% CI, 1.80–20.8; P = 0.0037), but not in ARPI (HR, 0.37: 95% CI, 0.043–3.20; P = 0.37). The gene discussed is TF; the disease is bone metastasis.