Conversely, the depletion of endogenous E75 resulted in apoptosis (Fig. 3F) and caused a reduction in clone size, as well as adult wing and eye size (Figs. 3C,C’ and EV2D), to the same degree as observed during the activation of the Hippo signaling pathway or knockdown of yki. Additionally, inhibition of E75 also suppressed tumor overgrowth induced by scrib−/−,wts−/− (Figs. 3C,C’ and EV2D). This evidence concerns the gene YAP1 and neoplasm.