The activation of the transcription complexes of Hippo and Notch pathways, namely the YAP/TAZ-TEAD and NICD-RBPJ-MAML complexes, respectively, promotes tumor progression and malignancy, including glioblastoma (GBM), a highly aggressive type of brain cancer (Orr et al, 2011; Purow et al, 2005). The gene discussed is NOTCH1; the disease is neoplasm.