In the presence of surrounding wild-type (WT) cells, the scrib mutant clones undergo elimination through a conserved process known as tumor-suppressive cell competition (Figs. 1A,B and EV1A) (Brumby and Richardson, 2003; Katsukawa et al, 2018; Kong et al, 2022; Sanaki et al, 2020; Zheng et al, 2023). The gene discussed is SCRIB; the disease is neoplasm.