LCN2 and obesity due to melanocortin 4 receptor deficiency: Additionally, LCN-2 is considered an inflammatory mediator as it is induced by proinflammatory cytokines IL-6, IFN-γ and TNF-α in adipocytes, neutrophils, and macrophages and is involved in inflammatory pathologies such as obesity, inflammatory bowel disease, type 2 diabetes, and others4.