Additional mutations known to be involved in AJ CRC predisposition include the c.1906G>C mutation in MSH2 [10, 11], c.3959_3962delCAAG, c.3956_3959delAAGC and c.3984_3987dupGTCA [12] in MSH6, and a GREM1 40 kb upstream duplication [13]. Here, MSH2 is linked to colorectal carcinoma.