CART analysis using TCGA, Lauren, GII and p53/CDH1 revealed a decision tree that first divided tumors TCGA’s classification, and secondly by Lauren in the CIN group only, which resulted in three prognostic relevant subgroups: GS, CIN-intestinal, and CIN-diffuse. The gene discussed is CDH1; the disease is cervical squamous intraepithelial neoplasia.