GBM samples were regulated by FOXS1 and HEY1, while MB samples were regulated by AEBP1 and TBX18. Normal tissue samples were driven by previously mentioned regulators but also MEF2C and TSC22D4. A third meta-module (#12) showed a slightly weaker enrichment for the microvascular proliferation signature and included all types. The gene discussed is HEY1; the disease is glioblastoma.