IGF1 and muscle cramp: Fig. 9C compares recordings from a vehicle- and a (1–3)IGF-1-treated rat in the week following treatments. While all TTX-infused rats (seven out of seven) treated with vehicle continued to have spasms, the majority of (1–3)IGF-1-treated rats (five of six) were seizure-free (Fig. 9E). (1–3)IGF-1 produced a 96% decrease in daily spasm counts compared to vehicle-treated epileptic rats (Fig. 9D).