TG and memory impairment: This hippocampal T3 infusion rescued long-term ORM deficit in HFS ad lib mice without affecting performance of NC ad lib mice (one-sample t test against 50%: p < 0.02 for all groups except HFS ad lib; 2-way ANOVA interaction diet x TRF p < 0.001, HFS ad lib p < 0.01 compared to all other groups, Figure 6F) demonstrating that deficient thyroid hormones action in hippocampus plays an important role in the memory impairments of HFS ad lib mice.