TBX15 and Abdominal obesity: Taken together, we found evidence for a north-south difference among the global allele frequencies with the abdominal obesity GWAS TBX15 missense variant rs10494217, where a higher frequency of the T allele, the risk allele for abdominal obesity, appears in more northern countries with colder climates than in the southern warmer countries, in line with the previous animal studies reporting a thermogenic effect of Tbx15.12