TF and Abdominal obesity: Taken together, we found putative evidence for selection with a north-south descending allele-frequency gradient of an abdominal obesity GWAS SNP, rs10494217, a predicted deleterious missense variant in a unique adipocyte marker gene, known adipose TF, and mouse thermogenesis gene, TBX15. The risk allele status of this TBX15 missense variant also impacted the SAT adipocyte expression of 13 unique adipocyte marker genes consistently in two independent Finnish bariatric surgery cohorts, KOBS and RYSA.