TBX15 and Abdominal obesity: We investigated this hypothesis and first observed that there is a north-to-south gradient and a large variation in the allele frequencies of the identified abdominal obesity GWAS missense variant in TBX15 across global populations from different ancestries when compared to Finns, a well-known genetic isolate with a distinct population history that includes multiple bottlenecks and displays founder effects in rare monogenic diseases.16