We found replicated changes in adipocyte expression of 13 genes associated with the risk allele status of rs10494217, exemplifying how this potentially deleterious mutation could affect binding of Tbx15 to its downstream targets in trans. We also discovered that adipocyte expression of one of the 13 trans genes, lncRNA AC002066.1, is correlated with a nearby gene, CAV2. Both CAV2 and AC002066.1 were in turn significantly correlated with adipocyte size, which links these two genes and adipocyte hypertrophy, a metabolically unhealthy consequence of obesity, in a human cohort. This evidence concerns the gene TBX15 and obesity due to melanocortin 4 receptor deficiency.