TBX15 and Abdominal obesity: This design focused us on an abdominal obesity GWAS missense variant, rs10494217 (GenBank: NM_001330677.2) (c.466C>A [p.His156Asn]), predicted to be deleterious and residing in TBX15, a key adipose transcription factor (TF)8 that has been implicated for white adipocyte browning and thermogenesis in previous mouse studies.12