However, during hypertension onset at 10 weeks and robust hypertension at 16 weeks, the inflammatory markers Tnf, Il1b, Ccr1, Ccr5, Ilrn, and Ltb4r are statistically significantly upregulated in the kidney of female SHR vs WKY control (Fig 10A–10B). Here, LTB4R is linked to Hypertension.