This dataset represents an extension in scope of our previously published dataset from male SHR and WKY control including gene expression involved in inflammation, renin-angiotensin signaling, and sympathetic pathways from adrenal gland, kidney, and liver at time points corresponding to pre-hypertension (8 weeks), hypertension onset (12 weeks), and chronic hypertension (16 weeks) [13]. Here, REN is linked to hypertensive disorder.