However, during hypertension onset at 10 weeks and robust hypertension at 16 weeks, the inflammatory markers Tnf, Il1b, Ccr1, Ccr5, Ilrn, and Ltb4r are statistically significantly upregulated in the kidney of female SHR vs WKY control (Fig 10A–10B). The gene discussed is CCR5; the disease is hypertensive disorder.