Inflammatory markers, including Tlr3 and Bcl6, are upregulated in the adrenal gland early on during pre-hypertension at 8 weeks in female SHR vs. WKY, while other inflammatory markers, including Tnf, Il1b, and Ltb4r, are upregulated in the kidney at later time points including hypertension onset at 10 weeks and established hypertension at 16 weeks in female SHR vs. WKY control (Fig 8A). This evidence concerns the gene TNF and hypertensive disorder.