We directly assessed the role of necroptosis in the liver on CLD and liver cancer using two knockin mouse models in which two genes involved in necroptosis (Ripk3 and Mlkl) were overexpressed specifically in liver (hepatocytes): hRipk3-KI and hMlkl-KI mice [24]. The gene discussed is RIPK3; the disease is congenital secretory chloride diarrhea 1.