In this study, male hRipk3-KI, hMlkl-KI, and control (Ripk3-KI and Mlkl-KI) mice were fed a WD to induce obesity starting at 2 months of age and compared to mice fed a standard laboratory chow diet (CD). This evidence concerns the gene RIPK3 and obesity due to melanocortin 4 receptor deficiency.