MLKL and congenital secretory chloride diarrhea 1: We directly assessed the role of necroptosis in the liver on CLD and liver cancer using two knockin mouse models in which two genes involved in necroptosis (Ripk3 and Mlkl) were overexpressed specifically in liver (hepatocytes): hRipk3-KI and hMlkl-KI mice [24].