And the transcript levels of Myc, which has been called the “grand orchestrator of cancer growth and immune evasion” [71] and was one of the first oncogenes found amplified in hepatocellular carcinoma [72], were significantly increased in both hRipk3-KI and hMlkl-KI mice at 14 months of age compared to control mice fed the WD. This evidence concerns the gene MYC and hepatocellular carcinoma.