Because Ripk3 and Mlkl are involved in pathways other than necroptosis, it was important for us to show that similar changes in CLD and liver cancer occurred in both hRipk3-KI and hMlkl-KI mice to demonstrate conclusively that necroptosis was responsible for the changes that we observed. This evidence concerns the gene MLKL and congenital secretory chloride diarrhea 1.