TMA immunostaining (Fig. 1C) for c-MET revealed H-scores of 82.51 ± 6.41 (NSE, n = 29), 92.00 ± 5.45 (inflammatory esophageal tissue, n = 50), 112.50 ± 6.20 (hyperplasia, n = 68), and 205.80 ± 6.74 (esophageal adenocarcinoma, n = 104), respectively (Fig. 1D). The gene discussed is ENO2; the disease is esophageal adenocarcinoma.