Efforts to increase diagnostic accuracy through FME have investigated several molecular markers such as EGFR, ErbB2 receptor tyrosine kinase 2, VEGF-A, fluorescent PARP1 inhibitor, chemokine receptor 4, heat shock protein 70, and c-MET for early esophageal adenocarcinoma detection (13, 15, 16, 40–43). Here, PARP1 is linked to esophageal adenocarcinoma.