In particular, according to the Kyoto Encyclopaedia of Genes and Genomes (KEGG) database KRAS and RASGRF2 genes from the Ras signalling network were found to contribute also to the Pathways in Cancer functions (Figure 3A), especially by interacting with the identified candidate introgressed loci PLCB1, RASGRP2, DAPK1, MAPK1, FOS, and VEGFA to modulate the VEGF signalling pathway, which is activated in hypoxic conditions and induces the transcription of genes that promote angiogenesis (Figure 3A; Maxwell and Ratcliffe, 2002; Kranenburg et al., 2004). This evidence concerns the gene RASGRF2 and cancer.