For instance, accumulation of the HIF-1α transcriptional factor in the nucleus of cells close to hypoxic tumour masses comports the activation of diverse biological responses such as the formation of dense capillary structures that permit oxygen and nutrients supplies to cancer cells, thus determining tumour progression and/or treatment failure (Brahimi-Horn et al., 2007; Calderón - Gerstein and Torres - Samaniego, 2021). Here, HIF1A is linked to neoplasm.