While some potential FABP4 receptors, such as membrane phospholipids (Hao et al., 2018b), desmoglein 2 (Chen et al., 2023), cytokeratin 1 (Saavedra et al., 2015), have been reported in various cell types, further investigations are needed to determine how FABP4 and its lipid ligands facilitate tumor metastasis - either by initiating oncogenic signals, by providing energy sources or both. This evidence concerns the gene FABP4 and neoplasm.