Utilizing a combination of in vitro cellular studies with various species of FAs, in vivo macrophage single-cell sequencing in mouse models, and macrophage/FABP4 analysis in human breast cancer specimens, we demonstrate that FABP4 plays a pivotal role in mediating lipid droplet formation and subsequent lipolysis for tumor utilization, thus contributing to TAM-mediated tumor growth and metastasis in breast cancer. Here, FABP4 is linked to breast carcinoma.