Another large OV, the HSV, was genetically engineered to express angiostatin (an endogenous inhibitor of angiogenesis) and bevacizumab, and it was applied in a human glioblastoma mouse model and showed tumor lysis and angiostatin-mediated VEGF inhibition, suppressing invasive phenotypes with higher survival time values [162]. The gene discussed is PLG; the disease is neoplasm.