AR and Familial prostate cancer: Recent studies found that BRD4 can regulate histone crotonylation in prostate cancer cells by regulating the expression levels of histone acetyltransferase, GCN5, and p300, while in androgen-dependent prostate cancer cell line LNCaP and castration-resistant prostate cancer cell line C42B, histone crotonylation can specifically activate the androgen receptor signaling pathway, thereby promoting cell proliferation, migration, and invasion [60].