In colon cancer cells with p53 deficiency, the significant increase in K283 crotonylation in cisplatin resistance-related genes (RRM2) leads to increased cisplatin resistance-related genes ATP7A, ATP7B, and MUC16, while the expression of cleaned-PARP1 and cleaned-caspase3 decreases. This evidence concerns the gene RRM2 and malignant colon neoplasm.