HDAC6 and hepatocellular carcinoma: Zhang et al. demonstrated that crotonylation of proteins is very sensitive to fluctuations of oxygen concentration, whereby hypoxia promotes crotonylation, the interaction of HDAC6 with Lamin A contributes to crotonylation, and HDAC6 is downregulated under hypoxia conditions, which leads to the crotonylation of Lamin A and increased proliferation of HCC.