The inhibition of NF-κB signaling by an shRNA to the p65 subunit of NF-κB or by the overexpression of a super-repressor of IκB (IκB-SR) reduced the level of cyclin D2 in LS 174T CRC cells expressing L1 (Figure 5A, cyclin D2, Supplementary Figure S1A), suggesting that this pathway is involved in the induction of cyclin D2 by L1. The gene discussed is NFKB1; the disease is colorectal carcinoma.