CCND2 and colorectal carcinoma: In addition, we found that by inhibiting the proteasomal degradation of β-catenin with the proteasomal inhibitor MG132, the cyclin D2 protein level was elevated in LS 174T CRC cells expressing L1, further supporting the involvement of the Wnt/β-catenin pathway in this process (Supplementary Figure S2A–C).