This increase in tumor size and weight required the induction of cyclin D2 by L1 since the suppression of cyclin D2 levels by shRNA compared to cyclin D2 blocked the increased tumor growth induced by L1 (Figure 4B, L1+shcyclin D2 cl1, and cl2, compared to L1 cl2). The gene discussed is CCND2; the disease is neoplasm.