The results presented in Figure 3A show that L1-expressing CRC cell clones in which the endogenous levels of cyclin D2 were suppressed by shRNA compared to cyclin D2 displayed a decreased ability to proliferate, similar to control pcDNA3-transfected cells (Figure 3A, L1+shcyclin D2 cl1, and cl2 compared to pcDNA3 and L1 cl2). Here, CCND2 is linked to colorectal carcinoma.