TRPM7 and breast carcinoma: Additionally, many investigators used NS8593 or other TRPM7 inhibitors, often in combination with RNAi silencing of TRPM7, to demonstrate the crucial role of TRPM7 in signaling pathways and cellular processes linked to tumor progression [25,35,38,40,42,43,44,45], including breast cancer [38,46,47,48,49,50,51].