As shown in Figure 6A,B, tumors in mice injected with USP1−/− UMUC3 cells grew markedly slower than those in mice injected with UMUC3 cells, and the tumor volume in nude mice injected with USP1−/− UMUC3 cells was significantly smaller than that in nude mice injected with the WT UMUC3 cells (Figure 6C). Here, USP1 is linked to neoplasm.