Studies on intestinal ischemia-reperfusion injury showed that EPA at 0.3 g/kg/day conferred protective effects by alleviating inflammation and reducing both injury severity and HMGB1 expression [150,151] and had some protective effects in relieving inflammation by inhibiting the expression and signal transmission of TLR4 mRNA [151]. This evidence concerns the gene HMGB1 and ischemia reperfusion injury.