The tumor immune microenvironment (TIME) can be classified as T1 (TIL−, PD-L1−), T2 (TIL+, PD-L1+), T3 (TIL−, PD-L1+), and T4 (TIL+, PD-L1−), of which, T2 is most responsive to ICIs [29]. This evidence concerns the gene CD274 and neoplasm.