CD274 and neoplasm: The absence of T2, or IFN-γ deficiency in T3, or lack of PD-L1 in T1, ectopic expression of PD-L1 on tumor-associated macrophages/platelets, or presence of driver mutations in EGFR/ALK/ROS1/MET/RET, or presence of secreted PD-L1, forms sets of different probable events leading to ICI-resistance [48,49,50,51,52,53,54].