The most frequent mutations in NSCLC include exon 19 deletion (45–50% of all EGFR mutated cases) and exon 21 substitution (L858R) (35–45% of all EGFR mutated cases) that are commonly found in non-smoking women from East Asia with adenocarcinoma [76]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.