, and rearrangements (rearr) have been implicated in the development of aggressive NSCLC, including KRAS (mut), EGFR (mut), FGFR1 (amp), ALK (rearr), HER2 (mut), MET (amp), and many other rare alterations in BRAF, PIK3CA, AKT1, MEK1, NRAS, RET, RB1, and NTRK (Table 1) [2]. The gene discussed is ALK; the disease is non-small cell lung carcinoma.