HAVCR2 and glioblastoma: As HAVCR2 (TIM-3) and ENTPD1 (CD39) gene expression levels were elevated in the glioblastoma micro-environment, we next compared the percentage positive levels of TIM-3 and CD39 on T and NK cells from glioblastoma versus healthy donor PBMCs ± stimulation with PMA and ionomycin using flow cytometry (patient and healthy control characteristics are listed in Supplementary Table S1).