The potential TIM-3-dependent, FOXO1- and BLIMP1-independent mechanism of T cell dysfunction may also be evident in NK cells from glioblastoma patients, where the impaired reduction in the percentage of TIM-3 positivity after stimulation and the reduced percentage of BAT3 positivity are correlated with significant decreases in CD69 and IFNγ compared to control donors. Here, FOXO1 is linked to glioblastoma.