We have recently shown that Prom1-KO activates mTORC1, reduces TFEB activity, and induces epithelial–mesenchymal transition (EMT) in mouse RPE (mRPE) cells, demonstrating that Prom1-mTORC1-TFEB signaling is a central driver of cell-autonomous mRPE homeostasis and suggesting a possible role in the development of geographic atrophy (GA) [18]. The gene discussed is TFEB; the disease is atrophic macular degeneration.