PROM1 and age-related macular degeneration: The dimensionality reduction plot using the same dataset was used to distinguish AMD RPE from control RPE clusters (. Mapping the AMD RPE cells to their respective control conditions using Spectacle showed varied Prom1 expression in a few control cells vs. AMD RPE (i.e., RPE2, RPE3, and RPE4), highlighting Prom1’s important role in maintaining RPE function and health, and suggesting that its dysregulation can have significant implications for RPE homeostasis, particularly in the context of AMD (Figure 9D).