IDH1 and astrocytoma (excluding glioblastoma): Indeed, the core of the glioblastoma showed differences in IDH-wildtype versus astrocytoma, IDH-mutant grade 4, with a reduced proportion of cytotoxic/immature NK cells and a higher frequency of macrophages but not microglia, suggesting an increased peripheral margination and invasion of the tumoral core by macrophages proportional to disease severity [33].