The additional serious complications during treatment were reported in seven patients (two of pulmonary tuberculosis, one of multiple organ dysfunction, one of intracranial infection, one of renal failure and two of severe COVID‐19), with three deaths. CD4 and CD4/CD8 decreased slightly from baseline (251.76+188.53 and 0.71+0.69) at the sixth month (233.44+140.528 and 0.66+0.55) and there was no statistical difference (p = 0.375 and p = 0.608). The gene discussed is CD4; the disease is pulmonary tuberculosis.