Conclusions: After switching from triple therapy to DTG/3TC, and more than a year of follow‐up, this diverse migrant population, with a long duration of infection and potentially significant previous therapeutic variability, showed no treatment discontinuations; minimal impact on average weight and BMI; immunological status was maintained, with an increase in absolute CD4 count and CD4/CD8 ratio; and a sustained virological suppression in all patients. Here, CD4 is linked to infection.