Inclusion criteria include untreated HIV‐1, HIV‐RNA >1000 copies/ml, and at least one of the following: (1) AIDS‐defining condition/any CD4 count; (2) severe bacterial infection/CD4 <200/μl; (3) any or no symptoms/CD4 <100/μl; and (4) serious opportunistic infection currently under treatment. This evidence concerns the gene CD4 and Opportunistic infection.