Several genes codedfor proteins that impact mitochondrial function and biogenesis in multiple ways:FUS (fused in sarcoma) encodes a multifunctionalDNA/RNA-binding protein that was reported to interact with the mitochondrial ATPsynthase beta subunit (ATP5B) and induces mitochondrialdysfunction under stress conditions (53).HTT (huntingtin) was identified as mutated in theneurodegenerative disorder of Huntington’s disease and is involved in anumber of cellular processes including cytoskeletal anchoring, vesicletransport, mitochondria dysfunction, and autophagy (54, –, 56). The gene discussed is HTT; the disease is Huntington disease.