CHRM1 and Scheie syndrome: In summary, for MPV prevention, we fabricated a bionic self‐adjuvant vaccine AM@AEvs‐PB based on MPV antigens pre‐activated macrophage‐derived vesicles, loading with the IMV protein (A29L and M1R), combining with EEV antigen (B6R) superficially to effectively counter MPV replication cycles.