In human endometrial cancer, Li et al. found that CypA knockdown by lentiviral shRNA (LV-shCypA) suppressed the migratory/invasive capacity of HEC-1-B cells, likely due to the down-regulation of focal adhesion signaling.107 Importantly, MMPs, key factors in the degradation of the extracellular matrix (ECM) in cancer, have been associated with cell invasion and migration. The gene discussed is PPIA; the disease is endometrial cancer.