PKM and cancer: In breast cancer, CsA hampers cell proliferation by affecting glycolysis, particularly by downregulating the pyruvate kinase subtype M2 (PKM2).113 In lung adenocarcinoma, CsA is seen to suppress cancer cell growth by inducing apoptosis.120 Consistently, recent studies reveal CsA’s ability to boost docetaxel-induced apoptosis in human gastric carcinoma, suggesting its potential in cancer therapy.