In cells stimulated by extracellular CypA, pathways like extracellular signal-regulated kinase 1 and 2 (ERK1/2), nuclear factor kappa-B (NF-κB), protein kinase B (AKT), Jun N terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) become activated.47–50 Recent studies highlight CypA’s overexpression in several cancer types, including gastric, breast, colorectal, liver, lung, and melanoma. This evidence concerns the gene MAPK8 and cancer.