PPIA and cancer: In human endometrial cancer, Li et al. found that CypA knockdown by lentiviral shRNA (LV-shCypA) suppressed the migratory/invasive capacity of HEC-1-B cells, likely due to the down-regulation of focal adhesion signaling.107 Importantly, MMPs, key factors in the degradation of the extracellular matrix (ECM) in cancer, have been associated with cell invasion and migration.