Additional studies are needed to determine the clinical relevance of these findings and whether or not these electrolyte abnormalities in cats with CIE could be caused by failure to upregulate ENaC or loss of function of ENaC, induction of intestinal transmembrane ACE2, or dysregulated expression or function of the renin‐angiotensin pathway, or other intestinal electrolyte transporters. The gene discussed is ACE2; the disease is congenital non-bullous ichthyosiform erythroderma.