In patients without somatic GNAS mutations, females displayed much higher baseline GH levels (17.30 (10.70, 61.73) vs 10.55 (5.25, 16.95) ng/mL, P = 0.018), a greater prevalence of abnormal glucose metabolism (47.2 vs 16.7%, P = 0.028) and dyslipidemia (56.7 vs 20.0%, P = 0.020) when compared to males. This evidence concerns the gene GNAS and metabolic syndrome.