For instance, PET scanning of 68Ga‐NOTA‐C25 revealed that LAG‐3 expression and LLC tumor uptake were both significantly increased after treated by a stimulator of interferon genes agonist or combined with PD‐1 inhibitors.[13] In a preliminary clinical study, 89Zr‐BI 754 111 demonstrated specific binding to LAG‐3 in a limited cohort of cancer patients, with tumor uptake correlating with immune cell‐derived RNA signatures.[14] However, the relationship between tracer tumor uptake and IHC expression levels of LAG‐3 has not been fully illustrated in these studies. This evidence concerns the gene PDCD1 and cancer.